"pick-me-up" 合起来是一个词,表示"能让人振作起来、让人心情好起来的东西"
Here is another example - If you receive a birthday card from your best friend, you must feel good. So, the card for you is a "pick-me-up".
lay off something意思是"停止做某件事", lay off someone意思是"别烦某个人"。
I think that maybe the doctors should lay off the painkillers.
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